Reversal effect of nimodipine on cytarabine-resistant HL60 cells associated with triggering apoptosis
نویسندگان
چکیده
1 Department of Pediatric Hematology,The Affiliated Hospital of Medical College, Qingdao University, NO.16, Jiangsu Road, Shandong 266003, P. R. China. 2 Department of Stomatology, Weihai municipal hospital, No.70, Heping Road, Shandong 264200, P. R. China. 3 Department of Pediatric Hematology, the Affiliated Hospital of Medical College, Qingdao University, No.16, Jiangsu Road, Shandong 266003, P. R. China. 4 Department of Pharmacy, the Affiliated Hospital of Medical College, Qingdao University, No.16, Jiangsu Road, Shandong 266003, P. R. China. 5 Second department of internal medicine, Qingdao Children’s hospital, No.27, Wuding Road, Shandong, 266003, P. R. China.
منابع مشابه
RNAi Induced Inhibition of MRP1 Expression and Reversal of Drug Resistance in Human Promyelocytic HL60 Cell Line
Multidrug resistance (MDR) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. Nevertheless, in most drug resistant cell lines and cancer patients up-regulation of ABC-transporter genes such as MDR associated Protein (MRP1) gene could be at the basis of the drug resistance phenotype. We aimed to decre...
متن کاملبررسی اثرات سیتوتوکسیک، تمایز و ایجاد آپوپتوز عصاره گیاهی ویسکام آلبوم بر روی سلولهای لوسمیک HL60 به تنهایی و در ترکیب با ATRA
Background & Aim: Acute promyelocytic Leukemia(APL) is a kind of acute leukemia characterized by a balanced t(15, 17) translocation and the accumulation of neoplastic promyelocytes which fails to develop into mature cells. In the recent years, chemotherapy, differentiation agents and apoptotic drugs have beed used in treatment of leukemia. Recently, plant extracts have been used for treatme...
متن کاملInduction of Apoptosis in Human Leukemia Cell Line (HL60) by Animal’s Venom Derived Peptides (ICD-85)
Our previous studies revealed an inhibitory effect of ICD-85 (Venom derived peptides) on breast cancer cell line MDA-MB231. ICD-85 was also confirmed by in-vivo studies to suppress the breast tumor in mice. However, the exact mechanism of ICD-85 was unknown. Hence, the present study was undertaken to assess the mechanism of ICD-85 effect as an anti-proliferative agent of cancer cells. The effec...
متن کاملاثر محافظتی سیتوکین SCF در مهار آپوپتوز ناشی از اشعه X در سلول های HL60
Background and purpose : Âpoptosis or programmed cell death is a process of cell suicide. Ïonizing radiation is one of the stimuli for apoptosis, acting through DNÂ damage. Ïn the present study, effects of X-rays induced apoptosis in HL60 cells, as well as the protective effects of Stem Çell Factor (SÇF) in inhibiting X-ray induced apoptosis have been evaluated. Materials and methods : HL6...
متن کاملInduction of Apoptosis in Human Leukemia Cell Line (HL60) by Animal’s Venom Derived Peptides (ICD-85)
Our previous studies revealed an inhibitory effect of ICD-85 (Venom derived peptides) on breast cancer cell line MDA-MB231. ICD-85 was also confirmed by in-vivo studies to suppress the breast tumor in mice. However, the exact mechanism of ICD-85 was unknown. Hence, the present study was undertaken to assess the mechanism of ICD-85 effect as an anti-proliferative agent of cancer cells. The effec...
متن کامل